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NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats. M. S. Krestina, O. B. Shevelev, I. V. Koptyug, L. A. Gerlinskaya, S. E. Peltek, A. E. Akulov

Abstract: We have evaluated the efficiency of a metabonomic approach to metabolic phenotyping and detection of early metabolic changes under a toxic influence. For this purpose, a metabolic profiling of rat liver was performed with 1H NMR spectroscopy. Rat tissues …

Рубрика: Tom 19-4 | Comments Off on NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats. M. S. Krestina, O. B. Shevelev, I. V. Koptyug, L. A. Gerlinskaya, S. E. Peltek, A. E. Akulov

Role of intestinal mucin-2 in the effectiveness of the treatment of Helicobacter spp. infection in laboratory mice. E. A. Litvinova, M. D. Belyaev, A. V. Prokhortchouk, V. S. Korostina, E. B. Prokhortchouk, E. N. Kozhevnikova

Abstract: Abnormal synthesis of the main intestinal proteo­glycan mucin-2 is typical of ulcerative colitis and Crohn’s disease in humans. Those morphological changes of the mucus layer affect the diversity of the intestinal microflora. Antibiotics may be ineffective or even dangerous …

Рубрика: Tom 19-4 | Comments Off on Role of intestinal mucin-2 in the effectiveness of the treatment of Helicobacter spp. infection in laboratory mice. E. A. Litvinova, M. D. Belyaev, A. V. Prokhortchouk, V. S. Korostina, E. B. Prokhortchouk, E. N. Kozhevnikova

Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy. K. A. Titova, Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, Ar. A. Sergeev, D. O. Galahova, A. S. Zamedyanskaya, L. N. Shishkina, O. S. Taranov, V. V. Omigov, E. L. Zavjalov, A. P. Agafonov, A. N. Sergeev

Abstract: At present, there is no animal model for smallpox that reflects the weakened immune system in people and can therefore help assess the prophylactic (highly preventive) efficiency of antiviral drugs. To fill in the gap, we have explored the …

Рубрика: Tom 19-4 | Comments Off on Possibility of using a mouse SCID as a model animal to variola virus for evaluating anti-smallpox drug efficacy. K. A. Titova, Al. A. Sergeev, A. S. Kabanov, L. E. Bulychev, Ar. A. Sergeev, D. O. Galahova, A. S. Zamedyanskaya, L. N. Shishkina, O. S. Taranov, V. V. Omigov, E. L. Zavjalov, A. P. Agafonov, A. N. Sergeev

A model of the artificial metastasis of human epidermoid carcinoma A431 in nude mice for examination of the oncolytic activity of vaccinia virus. G. V. Kochneva, A. A. Grazhdantseva, G. F. Sivolobova, A. V. Tkacheva, A. N. Shvalov, A. Yu. Unusova, E. I. Ryabchikova, S. V. Netesov

Abstract: Human carcinoma A431 cells were subcutaneously injected into nude mice at points remote from each other. One of the two xenografts developed after­wards was used for treatment with a recombinant vaccinia virus, while another served as an artificial metastasis. …

Рубрика: Tom 19-4 | Comments Off on A model of the artificial metastasis of human epidermoid carcinoma A431 in nude mice for examination of the oncolytic activity of vaccinia virus. G. V. Kochneva, A. A. Grazhdantseva, G. F. Sivolobova, A. V. Tkacheva, A. N. Shvalov, A. Yu. Unusova, E. I. Ryabchikova, S. V. Netesov

Correlation of susceptibility to ortho-aminoazotolueneinduced hepatocarcinogenesis with Car and Ahr signaling pathway activation in mice. N. V. Baginskaya, E. V. Kashina, M. Yu. Shamanina, S. I. Ilnitskaya, V. I. Kaledin, V. A. Mordvinov

Abstract: Ortho-aminoazotoluene (OAT) is a potent hepatocarcinogen for most strains of mice. It has previously been shown that OAT application activates the aryl hydrocarbon receptor (Ahr) and the constitutive androstane receptor (Car) in the mouse liver. Both of these receptors …

Рубрика: Tom 19-4 | Comments Off on Correlation of susceptibility to ortho-aminoazotolueneinduced hepatocarcinogenesis with Car and Ahr signaling pathway activation in mice. N. V. Baginskaya, E. V. Kashina, M. Yu. Shamanina, S. I. Ilnitskaya, V. I. Kaledin, V. A. Mordvinov

The morphofunctional and biochemical characteristics of opisthorchiasis-associated cholangiocarcinoma in a Syrian hamster model. G. A. Maksimova, M. Y. Pakharukova, E. V. Kashina, N. A. Zhukova, M. N. Lvova, M. V. Khvostov, D. S. Baev, A. V. Katokhin, T. G. Tolstikova, V. A. Mordvinov

Abstract: The validity of experimental models of pathologies is one of the key challenges in translational medicine. Cholangiocarcinoma, or bile duct cancer, ranks second among oncological diseases of the liver. There is a strong association between bile duct cancer and …

Рубрика: Tom 19-4 | Comments Off on The morphofunctional and biochemical characteristics of opisthorchiasis-associated cholangiocarcinoma in a Syrian hamster model. G. A. Maksimova, M. Y. Pakharukova, E. V. Kashina, N. A. Zhukova, M. N. Lvova, M. V. Khvostov, D. S. Baev, A. V. Katokhin, T. G. Tolstikova, V. A. Mordvinov

In vivo MRI visualization of growth and morphology in the orthotopic xenotrasplantation U87 glioblastoma mouse SCID model. E. L. Zavjalov, I. A. Razumov, L. A. Gerlinskaya, A. V. Romashchenko

Abstract: Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer with the average lifespan of patients about 9–12 months. The study of tumor formation and the evaluation of new therapies for GBM require accurate and reproducible …

Рубрика: Tom 19-4 | Comments Off on In vivo MRI visualization of growth and morphology in the orthotopic xenotrasplantation U87 glioblastoma mouse SCID model. E. L. Zavjalov, I. A. Razumov, L. A. Gerlinskaya, A. V. Romashchenko

Stress and arterial hypertension: ISIAH rat strain. Ye. V. Antonov, Yu. V. Alexandrovich, A. A. Seryapina, L. O. Klimov, A. L. Markel

Abstract: The main views of the issue of stress and hypertension are briefly reviewed. It is well known that stress is one of the major risk factors for cardiovascular disease development. Increase in blood pressure is a typical manifestation of …

Рубрика: Tom 19-4 | Comments Off on Stress and arterial hypertension: ISIAH rat strain. Ye. V. Antonov, Yu. V. Alexandrovich, A. A. Seryapina, L. O. Klimov, A. L. Markel

Changes in the transcriptome of the prefrontal cortex of OXYS rats as the signs of Alzheimer’s disease development. N. A. Stefanova, E. E. Korbolina, N. I. Ershov, E. I. Rogaev, N. G. Kolosova

Abstract: Alzheimer’s disease (AD) is the most prevalent neuro­degenerative disease. It produces atrophic changes in the brain, which cause dementia. The incidence of AD is increasing with increasing life expectancy and gradual aging of the population in developed countries. There are …

Рубрика: Tom 19-4 | Comments Off on Changes in the transcriptome of the prefrontal cortex of OXYS rats as the signs of Alzheimer’s disease development. N. A. Stefanova, E. E. Korbolina, N. I. Ershov, E. I. Rogaev, N. G. Kolosova

Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles. D. V. Petrovskii, A. V. Romashchenko, S. Yu. Troitskii, M. P. Moshkin

Abstract: Air pollution by particulate matter (PM) has been associated with cardiopulmonary morbidity and mortality in many recent epidemiological studies. It has been shown that transition metal compounds, well- known toxic components of PM, are able to induce hypothermia following …

Рубрика: Tom 19-4 | Comments Off on Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles. D. V. Petrovskii, A. V. Romashchenko, S. Yu. Troitskii, M. P. Moshkin