Joint Indo-Russian Workshop
"Systems Biology and Genome Informatics of M. tuberculosis and other infectious diseases"

October 12-14, 2008
Institute of Cytology and Genetics SB RAS,
Novosibirsk



  • MATERIALS OF THE WORKSHOP

  • PHOTOS

    Organizers:
    Institute of Cytology and Genetics SB RAS, Novosibirsk , Russia
    Institute of Genomics and Integrative Biology (IGIB), New Delhi, India
    The Vavilov Society of Geneticists and Breeders

    Russian organizer
    Prof. Nikolay Kolchanov, Acad., IC&G SB RAS
    Indian coordinator
    Dr. S. Ramachandran, IGIB, New Delhi, India

    Workshop topic:

    Mycobacterium tuberculosis is among the most hazardous disease-causing agents in humans. Recently, its threat has increased worldwide. This poses timely issues for countries, such as Russia and India. The problem is largely due to the emergence of new multiresistant variant forms of tuberculosis. Traditional approaches to treatment of these forms proved to be not consistently efficient. Novel therapeutic approaches and strategies are obviously needed. Development and improvement of methods based on approaches of genome informatics and systems biology, which consider features of M. tuberculosis and the human immune system, offer promise. Emphasis on these developments is worldwide, involving Russia and India. However close international collaboration, exchange of information and experience between multidisciplinary scientists would provide breakthroughs in this research area.

    In the last years, new knowledge about the genomic structure, metabolic and functional features of M. tuberculosis has accumulated in basic and applied medicine in Russia and India. At this junction, to better integrate the efforts of the Russian and Indian partners in resolution of the issues of tuberculosis and other infectious diseases, the Indo-Russian Joint Workshop "Systems Biology and Genome Informatics of M. tuberculosis and other infectious diseases" will be held.

    The aim of this workshop will be experience exchange and integration of the efforts of leading scientists in the area of bioinformatics in Russia and India. The seminar will be implemented within the framework of the approaches of systems biology and genome informatics for studying M. tuberculosis - human immune system interactions, developing new methods for combating tuberculosis and other infectious diseases.

    The following topics will be addressed at the workshop.
    1. Methods and algorithms of bioinformatics
    2. Protein-protein interactions
    3. Identification of novel metabolic pathways
    4. M. tuberculosis systems biology
    5. Novel methods for drug development
    6. Computational resources for drug development
    7. Problem of tuberculosis as a social diseases
    8. Mathematical modeling of the process of infectious diseases and metabolic pathways.
    9. Role of non-coding RNA in development of infectious diseases

    List of Russian participants

    1. Prof. Vadim Govorun, Research Institute of the Physico-Chemical Medicine of the Ministry of the Health protection and Social Development, Moscow
    2. Dr. Vladimir Ivanisenko, Institute of Cytology and Genetics SB RAS, Novosibirsk
    3. Prof. Nikolay Kolchanov, Academician, Institute of Cytology and Genetics SB RAS, Novosibirsk, Chairman
    4. Dr. Vitaly Likhoshvai, Institute of Cytology and Genetics SB RAS, Novosibirsk
    5. Dr. Vsevolod Makeev, State Research Center GosNIIGenetika, Moscow
    6. Dr. Nikolay Pertsev, Omsk Branch of the Sobolev Institute of Mathematics SB RAS
    7. Dr. Alexey Romanyukha, Institute of Numerical mathematics RAS, Moscow
    8. Dr. Alexey Rudko, Research Institute of Medical Genetics of Tomsk Scientific Center of Russian Academy of Medical Sciences, Tomsk, Russia
    9. Dr. Sergey Tat'kov, Institute of Cytology and Genetics SB RAS, Novosibirsk
    10. Prof. Valentin Topchii, Omsk Branch of the Sobolev Institute of Mathematics SB RAS
    11. Dr. Alexander Veselovsky, Institute of Biomedical Chemistry RAMS, Moscow

    List of Indian participants

    1. Prof. Manju Bansal, Molecular Biophysics Unit, Indian Institute of Science, Bangalore
    2. Dr. Debasisa Mohanty, National Institute of Immunology, New Delhi
    3. Dr. G.P.S. Raghava, Institute for Microbial Technology (CSIR), Chandigarh
    4. Dr. S. Ramachandran, Institute of Genomics and Integrative Biology, Delhi
    5. Dr. Vinod Scaria, Institute of Genomics and Integrative Biology, Delhi
    6. Dr. N. Srinivasan, Molecular Biophysics Unit, Indian Institute of Science, Bangalore
    7. Dr. Bhupesh Taneja, Institute of Genomics and Integrative Biology, Delhi
    The seminar will take place at tie Conference Hall of the Institute of Cytology and Genetics.

    Scientific program

    October 12, 2008
    Opening session
    16.00 Welcome remarks, workshop program announcement. Prof. Nikolay Kolchanov, Dr. Srinivasan Ramachandran
    16.15 "Bioinformatics at the Institute of Cytology and Genetics". A documentary movie. 16.30 Invited talk. The systems approach to anti-tuberculosis medicine. Prof. Vadim Govorun, Research Institute of the Physico-Chemical Medicine of the Ministry of the Health protection and Social Development
    17.30 Invited talk. Modeling of the tuberculosis spreading and analysis of factors influencing on the epidemic process. Prof. Alexey Romanyukha, Institute of Numerical mathematics RAS, Moscow October 13, 2008

    (45 min for talk+5min for questions=50 min per speaker)

    Time

    Speakers and Chair

    Tentative title

    9:30 A.M. - 10:20 A.M.

    Dr. S. Ramachandran, Institute of Genomics and Integrative Biology, Delhi

    The Mycobacterium tuberculosis SysBorg

    10:20 A.M. - 11: 10 A.M.

    Prof. Manju Bansal, Molecular Biophysics Unit, Indian Institute of Science, Bangalore

    Prediction of Promoters

    11: 10 A.M. - 11.30 A.M.

    TEA BREAK

     

    11:30 A.M. - 12:20 P.M.

    Dr. Vsevolod Makeev, State Research Center GosNIIGenetika, Moscow

    Analysis of bacterial genomic sequences

    12:20 P.M. - 1:10 P.M.

    Dr. Vinod Scaria, Institute of Genomics and Integrative Biology, Delhi

    Molecular Players in Host-Pathogen Interaction: Roles for noncoding RNAs

    1:10 P.M. - 2:15 P.M.

    LUNCH BREAK

     

    2:15 P.M. - 3:05 P.M.

    Dr. Debasisa Mohanty, National Institute of Immunology, New Delhi

    In silico identification of novel biosynthetic pathways by genome analysis

    3:05 P.M. - 3:55 P.M.

    Dr. Vitaly Likhoshvai, Institute of Cytology and Genetics SB RAS, Novosibirsk

    Mathematical modeling and computer analysis of gene networks

    3:55 P.M. - 4:15 P.M.

    TEA BREAK

     

    4:15 P.M. - 5:05 P.M.

    Dr. N. Srinivasan, Molecular Biophysics Unit, Indian Institute of Science, Bangalore

    Bioinformatics approach to detect protein-protein interactions

    5:05 P.M. - 5:55 P.M.

    Dr. Vladimir Ivanisenko, Institute of Cytology and Genetics SB RAS, Novosibirsk

    Drug targets discovery with text-mining and bioinformatics approaches: ANDCell and PDBSiteScan tools


    October 14, 2008

    Time

    Speakers and Chair

    Tentative title

    9:30 A.M. - 10:20 A.M.

    Dr. Bhupesh Taneja, Institute of Genomics and Integrative Biology, Delhi

    New Approaches to identifying drug targets using an integrative approach

    10:20 A.M. - 11: 10 A.M.

    Prof. Alexander Veselovsky, Institute of Biomedical Chemistry RAMS, Moscow

    Selection of new target proteins for drug design in genome of Mycobacterium tuberculosis

    11: 10 A.M. - 11.30 A.M.

    TEA BREAK

     

    11:30 A.M. - 12:20 P.M.

    Dr. G.P.S. Raghava, Institute for Microbial Technology (CSIR), Chandigarh

    Prediction algorithms for specificity and cross-rectivity of Kinase inhibitors

    12:20 P.M. - 1:10 P.M.

    Dr. Alexey Rudko, Research Institute of Medical Genetics of Tomsk Scientific Center of Russian Academy of Medical Sciences, Tomsk, Russia

    Genetic aspects of the tuberculosis susceptibility in Siberian populations

    1:10 P.M. - 2:15 P.M.

    LUNCH BREAK

     

    2:15 P.M. - 3:05 P.M.

    Dr. Nikolay Pertsev, Omsk Branch of the Sobolev Institute of Mathematics SB RAS

    Stochastic individual-based model of spreading of tuberculosis.

    3:05 P.M. - 3:55 P.M.

    Dr. Sergey Tat'kov, Institute of Cytology and Genetics SB RAS, Novosibirsk

    The role of the Beijing family of M.tuberculosis in the spread of multidrug-resistant tuberculosis in Novosibirsk region of West Siberia

    3:55 P.M. - 4:15 P.M.

    TEA BREAK

     

    4:15 P.M. - 5:05 P.M.

    Prof. Valentin Topchii, Omsk Branch of the Sobolev Institute of Mathematics

    Populations cutting at high level. Extinction time and time of supplanting all particles by particles of one type.

    5:05 P.M. - 5:55 P.M.

    Round Table discussion

     




    Financial Support



    Russian Foundation for Basic Research



    Department of Science and Technology, Ministry of Science and Technology, India





    PBSoft Ltd.