Model for depression and anxiety for medical-biological investigations

natnik@bionet.nsc.ru

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Description

An experimental depression model should meet 4 criteria of similarity with this disease in human: etiological, symptomatic, condition of animals is to improve treated with antidepressants, neurochemical changes in animal brain should coincide with those in depressive patients. At present the suggested model meets these criteria to the maximum. 
Etiological factors 
Chronic, emotional, social stress caused by daily aggressive confrontations, constant contact with a strong aggressive rival in one common space makes up the state of anxiety and fear maintained by constant expectance of an attack.

Symptoms 
General behavioral deficit suggesting itself both in individual and social behaviour, complete indifference similar to that of dynamic inhibition, lower dynamic activities in depressive patients, anxiety, phobia, helplessness. Somatic changes: decrease in body weight, water consumption, damages in gastric mucous, immune deficiency, higher corticosteroid level, sensitivity to antidepressants and anxyolitics. 
Neurochemical changes 
It was hypothesised and proved on the dynamic changes of metabolic processes and reception: the initial stage of depression progress is accompanied by activation of serotonergic activity and the stage of deep depression - by its distortion based on the condition of brain serotonergic system in individuals during the development of experimental depression.

Technical-Economic Advantages

The new experimental model of depression and anxiety in mice which is more adequate to the clinic of human depressive pathology on criteria of symptomatic similarity, etiology, sensitivity to antidepressants and anxyolitics, also emerging neurochemical changes in brain and exceeds the world model analogues used in such investigations in its thorough work-out. 
Based on the model, it is possible to conduct neurobiological researches of various psychoemotional frustrations accompanied by the progress of neuropsychoimmunodeficiency, aberration of cognitive functions, sexual and different psychosomatic diseases.

Fields of Application

The model could be used for many purposes of theoretical and experimental psychiatry, particularly, for the research of dynamic changes in activities of brain mediator systems in the process of progress and deepening of depression, screening new anxyolitics (antianxious) and antidepressants in modern pharmacology, studying specific neurochemical features of inherited predisposition towards the progress of depressive processes and anxiety in human, investigating the mechanisms of aberrations in cognitive processes affected by pathological factors of social origin, correction of immune deficiency, the interrelations between depression and alcoholism, correction of various somatic deviations caused by chronic social stress.

Level and Location of Practical Realisation

Experiments are being conducted at 5 institutes of Siberian Branch of the Russian Academy of Sciences and Russian Academy of Medical Sciences, Institute of Physiology, SB RAMS, Scientific-Research Institute of Bio-organic Chemistry, SB RAS, ICG, SB RAS, Scientific-Research Institute of Biology and Biochemistry based on agreements for scientific collaboration. Joint investigations are being carried out with the Institute of Neurosciences, Urtrecht, Netherlands, using the model.

Patent(s)

"Know-how'.

Commercial Proposals

Agreement on animals delivery.

Price List

To be determined during negotiations.

Contacts:

Natalia N. Kudriavtseva, 
Doctor of Biological Sciences 
Institute of Cytology and Genetics 
10 Lavrentiev ave., 
Novosibirsk, 630090, Russia 
Phone: +7(383) 334-47-53 
Fax: +7(383) 333-12-78 
E-mail: natnik@bionet.nsc.ru