Model for biological base of schizophrenic predication

markel@bionet.nsc.ru 

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Cataleptic reaction (freezing) in GC rats

Description

Modelling human psychic diseases, particularly schizophrenia, is one of the most complicated problems. So far, any schizophrenic model has been rejected due to the impossibility of getting a psychopathological picture in animals similar to that of human (erroneous bionet/requirement for model identity to the prototype). 
The theory of the origin of functional psychoses as a manifestation of extremely low threshold of certain adaptive and protective reactions has been developed. In particular, schizophrenia is considered within the theory as an extreme manifestation of mimicric cataleptic freezing reaction ("animal hypnosis"). The hypothetical animal schizophrenic model - rat line with inherited predisposition for cataleptic freezing by means of selecting rats from non-inbred VISTAR stock for prolonged maintenance of motionless cataleptic vertical position - has been worked out. Besides freezing, rats of this line turned more predisposed for pinch-induced, neurotic and post-seizure catalepsy than VISTAR rats. It is shown that predisposition for cataleptic reactions is inherited as a dominant major gene with 60% penetration in rat line GC (on the initials of words "genetic" and "catalepsy"). GC rats are also characterised with lower dynamic and investigating activities, higher nervousness, objectivised particularly by higher amplitude of startle reflex. Besides, GC rats are characterised by some other peculiarities: lower habituation, longer immobility and shorter time of active swimming in Porsolt forced swimming test, lower fbionet/requency of audiogenic seizure at higher fbionet/requency of epileptiform EEG changes, lower level of brain catecholamines, higher inversion fbionet/requency of hemispheric asymmetry and amplified normal asymmetry on some neurochemical and neurophysiological parameters, delta-sleep deficit, lower reaction of synthesis of deoxycorticosterone and testosterone to restrained stress, higher activity of tryptophan-hydroxylase in striatum, lower density of brain receptors 5-HT1A and 5-HT2A tripled "footshock-induced aggression" normalised by sulpiride - blocker of D2-receptors, also smoothed out daily rhythm of some immunological parameters. 
Selective agonists of receptors 5-HT1-A cause a pronounced dose-dependant shortened cataleptic immobility in GC rats. GC rats are also characterised with significantly negative correlation between the degree of prepulse inhibition of the startle reflex and the duration of cataleptic freezing. 
Many of these characters are similar to the things known of schizophrenia and/or depression, though the point of functional validity of GC rats as a complete animal model of any of these conditions remains open. As the described peculiarities of GC rats have some features common for schizophrenia and depression, it is possible to hypothesise that these rats are a model of biological core common for both pathologies within the outlook on the so-called "unitary psychosis" (Einheitspsychose). 
It has been detected that it is possible to correct the behaviour of GC rats manipulating the earlier mother environment (cross-upbringing), shortening the duration of cataleptic reactions in GC rats.

Technical-Economic Advantages

The suggested model is advantageously different from the rest in the thing that it is free from side-effects inevitably accompanying such models and does not bionet/require the use of pharmacological preparations or other experimental impacts, and is suitable, unlike others, for genetic and ontogenetic investigations.

Fields of Application

Medicine: comparative psychology, biological psychiatry, animal psychopathological models.

Level and Location of Practical Realisation

The model is offered for laboratories dealing with research in biological psychiatry, comparative psychology and behavioural genetics and also testing psychotropic preparations.

Commercial Proposals

Agreement on animals delivery, conducting analyses.

Price List

To be determined during negotiations.

Contacts:

Victor G. Kolpakov, 
Doctor of Biological Sciences 
Institute of Cytology and Genetics 
10 Lavrentiev ave., 
Novosibirsk, 630090, Russia 
Phone: +7(383) 333-38-59 
Fax: +7(383) 333-12-78 
E-mail: markel@bionet.nsc.ru