Institute Cytology and Genetics

Experimental Animal Breeding Laboratory

Head V.I.Ermolaev, Dr.Biol.Sci.

The Experimental Animal Breeding Laboratory has been founded almost at the same time as the Institute of Cytology and Genetics. It provides each year the Institute with animals required for the implementation of programs supported by 15 grants from the Russian Foundation for Basic Research and 20 grants from other agencies. The Laboratory supplies experimental animals through cooperation between academical research institutes in Siberia (Institute of Organic Chemistry, Institute of Biorganic Chemistry, Institute of Clinical Immunology, Institute of Biochemistry, Institute of Lymphology, State Sanitary Epidemiological Inspection, Institute of Traumatology and Orthopedy). The Laboratory contributes to the programs of four chairs of the Novosibirsk State University by providing access to experimental animals for both instruction and research.

The Laboratory maintains mice, rats, four vole species, rabbits.

At present, the number of adult mice maintained at the Laboratory is about 11,000. The total number of standard mouse strains and mutant stocks is 19. Of these, the most important are the following: A/Sn J, AKR/J, BALB/c Lac, CBA/Ca Lac, CC57Br/Mv Y, C3H/Sn Lac Y, C3HA/Mv Y, C57BI/ 6J Y, DBA/J Lac Y, DD/He, SWR/J Y. The strains differ in longevity, radiation resistance, predisposition development of organ, tissue pathologies and in other biological characteristics.

The average number of adult rats per month is 3,500. The following rat strains and stocks have been maintained and propagated over many generations: MSUBL/Icgn; WAG/G Sto Icgn; CHR/Icgn; BRATTLEBORO; W/SSM Icgn; W-RG/SSM Icgn; WISTAR-standard; GK/Icgn. It should be noted that most stocks have been developed by researchers at the Institute and that they have no counterparts in other animal breeding centers. The populations of other animals are insignificant. The Laboratory serves as the largest center for maintenance and breeding of animals to the east of the Ural mountains.