4. Sector of Methods of Genetic Analysis.
The home page of the Laboratory of the methods of genetic analysis is located at
http://mga.bionet.nsc.ru
(1) Staff:
- Tatyana I. Aksenovich, Ph.D., Head of the Sector
- Gulnara R. Svischeva
- Sergey V. Nikitin
- Irina V. Zorkoltceva
- Aleksey V. Filimonov
- Yurii S. Aulchenko
(2) Subject of Research:
Segregation and linkage analyses of pedigree data (theoretical
and applied aspects).
(3) General Results 1993-1995:
Methods have been developed for evaluation of the capacity of
linkage criteria, optimal planning of pedigree samples for linkage
analysis and a new method for ascertainment formalization of pedigrees
via proband.
Precision of the genetic prognosis using the data on gene linkage
was studied. New knowledge was obtained on the genetic control of
cholesterin concentration in blood and on a number of anthroposcopic
traits of man. Packages of programs were made for segregation analysis
of binary and quantitative traits.
(4) Publications:
- Axenovich T.I., Ginsburg E.Kh. (1993). On the planning of
samples for linkage analysis. I. Informativity of pedigrees. Genetika
29:1394-1403. (Rus.)
- Axenovich T.I., Ginsburg E.Kh. (1993). On the planning of
samples for linkage analysis. II. A sample size. Genetika 29:1544-1553.
(Rus.)
- Axenovich T.I., Ginsburg E.Kh. (1993). On the planning for
linkage analysis. III. Incomplete penetration. Genetika 29:1741-1749.
(Rus.)
- Ginsburg E.Kh. (1993). On a formalization of the correlative
ascertainment of pedigrees. Genetika 29:1391-1393. (Rus.)
- Ismailova Ch.S., Ginsburg E.Kh., Axenovich T.I., et al.
(1993). On a possibility of monogenic control of cholesterin
concentration in blood for Khirgizian population. Genetika
29:2081-2091. (Rus.)
- Ismailova Ch.S., Ginsburg E.Kh., Axenovich T.I., et al.
(1994). Segregation analysis of some anthroposcopic traits. I. Binary
traits with age-dependent penetrance. Genetika 30:843-850. (Rus.)
- Ismailova Ch.S., Ginsburg E.Kh., Axenovich T.I., et al.
(1994). Segregation analysis of some anthroposcopic traits. II. Age
dependence and traits with three types of phenotypic manifestation.
Genetika. 30:969-973.
- Axenovich T.I. (1995). Identification of linkage phase by
parental genotypes. Genetica 31:1168-1176. (Rus.)
- Axenovich T.I. (1995). On choosing pedigrees via proband.
Genetika 31:1693-1697.
- Axenovich T.I. (1995). Identification of linkage phase. Genet.
Epidem. 12:329-330.
(5) Participation in State and International Programs:
New Trends in Genetics
(6) Subjects of Scientific Collaboration:
- Development of the methods of genetic analysis of characters.
- Segregation analysis of characters in man using available
pedigree samples.